DNA and RNA Cleavage Complexes and Restore Pathway for TOP3B RNA– and DNA-Protein Crosslinks The current research demonstrates that topoisomerase 3B (TOP3B) varieties each RNA and DNA cleavage complexes (TOP3Bccs) in vivo and divulges a pathway for repairing TOP3Bccs. For inducing and detecting mobile TOP3Bccs, we engineer a “self-trapping” mutant of TOP3B (R338W-TOP3B). Transfection with R338W-TOP3B induces R-loops, genomic harm, […]